Can tumor necrosis factor α blockade predispose to severe babesiosis?

Severe babesiosis in a patient treated with a tumor necrosis factor α antagonist.

To the Editor—A 57-year-old woman from Cape Cod presented to our facility with fever and a syncopal episode. She reported 1 week of fatigue before her evaluation. On examination, she was febrile (38.6 C) but otherwise appeared well, with a positive Castell’s sign and palpable spleen tip. Her medical history was significant for Crohn’s disease treated with infliximab, with the most recent dose a...

Tumor Necrosis Factor-α Blockade and the Risk of Vasculitis

Blockade of Tumor Necrosis Factor α Signaling in Tumor-Associated Macrophages as a Radiosensitizing Strategy

Authors' A and 2Depa University Cell Biolo Amsterdam

Tumor necrosis factor- α, adiponectin and their ratio in gestational diabetes mellitus

Background: It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women with GDM compared with normal pregnancy and their relationships with metabolic syndrome ...

Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia

Background: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. Objective: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G- 308A), and (G-238A) in preeclemptic women northeastern Iran. Me...